研究方向：线粒体蛋白转运；植物光信号转导

招生方向：蛋白质结构与功能

实验室利用结构生物学和生物化学等多种手段，围绕线粒体的蛋白质转运和植物光信号转导展开研究，阐明了线粒体外膜转位酶复合体（TOM、SAM）和线粒体内膜转位酶复合体（TIM22转位酶复合体）转运线粒体蛋白的分子机制（Science, 2021; Cell Research, 2021; Cell Discovery，2021，2024）；系统揭示了植物感受紫外光、蓝光和远红光感光并进行光信号转导的分子机制（Cell Research，2023；Science Advances,2022；Nature Plants, 2020; Nature Structure Molecular Biology，2020，等）。实验室还密切关注RNA代谢通路相关蛋白复合体的结构与功能，揭示了RNA的甲基化修饰的分子基础（Nature，2016；Cell Research, 2022；Cell Discovery, 2023 a, b，等）。

代表性论文：

2024

Wang Y#, Qiu L#, Wang B#, Guan Z, Dong Z, Zhang J, Cao S, Yang L, Wang B, Gong Z, Zhang L, Ma W, Liu Z, Zhang D, Wang G* and Yin P*. Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex. Science. 2024. https://doi.org/10.1126/science.adn6881.

Wang Q#, Zhuang J#, Huang R#, Guan Z, Yan L, Hong S, Zhang L, Huang C, Liu Z, Yin P*. The architecture of substrate-engaged TOM–TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation. Cell Discovery. 2024(10)1:19. https://doi.org/10.1038/s41421-023-00643-y. 2024.2.16

2023

Yan X#, Liu F#, Yan J, Hou M, Sun M, Zhang D, Gong Z, Dong X, Tang C*, Yin P*. WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity. Cell Discovery. 2023(9)1. doi:10.1038/s41421-023-00604-5. 2023 Oct 3.

Wang J#, Zhou C#, Guan Z,Wang Q, Zhao J, Wang  L, Zhang L, Zhang  D, Deng X, Ma L*, Yin P*. Plant phytochrome A in the Pr state assembles as an asymmetric dimer. Cell Research. 2023,33(10):802-805. doi.org/10.1038/s41422-023-00847-7. 2023 Oct.

Yan J# , Liu F#, Guan Z, Yan X, Jin X, Wang Q, Wang Z, Yan J, Zhang D, Liu Z, Wu S*, Yin P*. Structural insights into DNA N6 -adenine methylation by the MTA1 complex. Cell Discovery. 2023,9(1):8. doi:10.1038/s41421-022-00516-w. 2023 Jan 20.

Wang L#, Wang Y#, Chang H, Ren H, Wu X, Wen J, Guan Z, Ma L, Qiu L, Yan J, Zhang D, Huang X*, Yin P*. RUP2 facilitates UVR8 redimerization via two interfaces. Plant Communications. 2023(9):100428. doi:10.1016/j.xplc.2022.100428. 2023 Jan 9.

Ma L, Jia H, Shen A, Ding J, Wang X, Wang J, Wan J, Yan J, Zhang D, Dong X*, Yin P*. Two determinants influence CRY2 photobody formation and function. Plant Biotechnology Journal, 2023,21(3):460-462. doi: 10.1111/pbi.13978. 2023 Mar.

2022

Yan X#, Pei K#, Guan Z#, Liu F, Yan J, Jin X, Wang Q, Hou M, Tang C*, Yin P*. AI-empowered integrative structural characterization of m6A methyltransferase complex. Cell Research. 2022,32 (12):1124-1127. doi:10.1038/s41422-022-00741-8. 2022 Dec.

Wang Y#, Wang L#, Guan Z#, Chang H, Ma L, Shen C, Qiu L, Yan J, Zhang  D, Li J, Deng X*, Yin P*. Structural insight into UV-B-activated UVR8 bound to COP1. Science Advances. 2022,8(16): eabn3337. doi:10.1126/sciadv.abn3337. 2022 Apr.

2021

Wang Q#, Guan Z#, Qi L#, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P*. Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex. Science. 2021,373(6561):1377-1381. doi: 10.1126/science.abh0704. 2021 Aug 26.

Guan Z#, Yan L#, Wang Q, Qi L, Hong S, Gong Z, Yan C*, and Yin P*. Structural insights into assembly of Human Mitochondrial Translocase TOM Complex. Cell Discov. 2021,7(1):22. doi: 10.1038/s41421-021-00252-7. 2021 Apr 13.

Zhan X#, Xue Y #, Guan Z#, Zhou C, Nie Y, Men S, Wang Q, Shen C, Zhang D, Jin S, Tu L*, Yin P*, and Zhang X*. Structural insights into homotrimeric assembly of cellulose synthase CesA7 from Gossypium hirsutum. Plant Biotechnology Journal.  2021,19(8):1579-1587. doi: 10.1111/pbi.13571. 2021 Aug.

Qi L#, Wang Q#, Guan Z#, Wu Y, Shen C, Hong S, Cao J, Zhang X, Yan C* and Yin P*. Cryo-EM structure of the human mitochondrial translocase TIM22 complex. Cell Res.  2021,31(3):369-372.doi: 10.1038/s41422-020-00400-w. 2021 Mar.

2020

Yan J#, Hong S#, Guan Z, He W, Zhang D, and Yin P*. Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1. Nat Commun. 2020,11(1):1417. doi: 10.1038/s41467-020-15242-8. 2020 Mar 17;

Ma L#, Wang X#, Guan Z Y#, Wang L X, Wang Y D, Zheng L, Gong Z, Shen C C, Wang J, Zhang D L, Liu Z and Yin P*. Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat. Struct. Mol. Biol. 2020,27(5): 472-479. (Comments by Prof. Chentao Lin, https://www.nature.com/articles/s41594-020-0432-6)

Shen C#, Liu H#, Guan Z, Yan J, Zheng T, Yan W, Wu C, Zhang Q, Yin P*, and Xing Y*. Structural insights into DNA recognition by CCT/NF-YB/YC complex in plant photoperiodic flowering. Plant Cell. 2020 Nov; 32(11):469-3484. DOI: https://doi.org/10.1105/tpc.20.00067

Ma L, Guan Z, Wang Q, Yan X, Wang J, Wang Z, Cao J, Zhang D, Gong X* and Yin P*. Structural insights into the photoactivation of Arabidopsis CRY2. Nat Plants. 2020 Nov 16. doi: 10.1038/s41477-020-00800-1.

2019

Yan J#, Yao Y#, Hong S, Yang Y, Shen C, Zhang Q, Zhang D, Zou T, Yin P*. Delineation of pentatricopeptide repeat codes for target RNA prediction, Nucleic Acids Research. 2019,47(7): 3728-3738. doi: 10.1093/nar/gkz075. 2019 Jan 31.

Huang J#, Dong X#, Gong Z#, Qin L, Yang S, Zhu Y, Wang X, Zhang D, Zou T, Yin P* and Tang C*.Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein&Cell. 2019,10(4):272-284. doi: 10.1007/s13238-018-0518-7. 2019 Apr.

2018

Wang X#, Guan Z, Gong Z, Yan J, Yang G, Liu Y, Yin P*. Crystal structure of WA352 provides insight into cytoplasmic male sterility in rice. BBRC. 2018 May 23; 501(4):898-904. doi.org/10.1016/j.bbrc.2018.05.079.

Huang J#, Yin P*. Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome. Genomics, Proteomics & Bioinformatics. 2018 Mar 29; 16(2):85-98. doi: https://doi.org/10.1016/j.gpb.2018.03.001

Ma L, Wang Q, Yuan M, Zou T, Yin P* and Wang S*. Xanthomonas TAL effectors hijack host basal transcription factor IIA α and γ subunits for invasion. BBRC. 2018 Jan 9; 496(2):608-613. doi: 10.1016/j.bbrc.2018.01.059.

Wang Q#, Zhang D#, Guan Z, Li D, Pei K, Liu J, Zou T and Yin P*. DapF stabilizes the substrate-favoring conformation of RppH to stimulate its RNA-pyrophosphohydrolase activity in Escherichia coli. Nucleic Acids Research. 2018 May 28. 46(13): 6880-6892. doi: 10.1093/nar/gky528.

Liu J, Guan Z, Liu H, Qi L, Zhang D, Zou T, and Yin P*. Structural insights into the substrate recognition mechanism of Arabidopsis GPP-bound NUDX1 for noncanonical monoterpene biosynthesis. Mol. Plant. 2018,11(1):218-221. doi:10.1016/j.molp.2017.10.006. 2018 Jan 8.

Yan J#, Zhang Q and Yin P*. RNA editing machinery in plant organelles. Sci China Life Sci. 2018,61(2):162-169. doi: 10.1007/s11427-017-9170-3. 2018 Feb.

2017

Yan J#, Zhang Q#, Guan Z, Wang Q, Li L, Ruan F, Lin R, Zou T, Yin P*. MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing. Nature Plants. 2017 Apr 10; 3:17037. doi: 10.1038/nplants.2017.37.

Wang X, Huang J, Zou T, Yin P*. Human m6A writers: Two subunits, Two roles. RNA Biol. 2017 Mar 4;14(3):300-304. doi: 10.1080/15476286.2017.1282025. Epub 2017 Jan 25.

Zhao W#, Zhou C#, Guan Z, Yin P*, Chen F* and Tang Y*. Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS Chem. Biol. 2017,12(3):746–752. doi:10.1021/acschembio.6b00842. 2017 Mar 17.

2016

Zhang D#, Liu Y#, Wang Q, Guan Z, Wang J, Liu J, Zou T, Yin P*. Structural basis of prokaryotic NAD-RNA decapping by NudC. Cell Research. 2016 Sep;26(9):1062-6. doi: 10.1038/cr.2016.98. Epub 2016 Aug 26.

Wang X#, Feng J#, Xue Y#, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P*. Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex. Nature. 2016,534(7608):575-8. doi: 10.1038/nature18298. 2016 Jun 23.

Shen C#, Zhang D#, Guan Z#, Liu Y, Yang Z, Yang Y, Wang X, Wang Q, Zhang Q, Fan S, Zou T, Yin P*. Structural basis for the specific single-stranded RNA recognition by designer pentatricopeptide repeat protein. Nat. Commun. 2016,7:11285.doi:10.1038/ncomms11285. 2016 Apr 18.

2015

Shen C#, Wang X#, Liu Y, Li Q, Yang Z, Yan N, Zou T, Yin P*. Specific RNA recognition by designer pentatricopeptide repeat protein. Mol Plant. 2015,8(4):667-70. doi: 10.1016/j.molp.2015.01.001. 2015 Apr;

2014

Li Q, Yan C, Xu H, Wang Z, Long J, Li W, Wu J, Yin P*, Yan N*. Examination of the dimerization states of the single-stranded RNA-recognition protein PPR10. J Biol Chem. 2014 Nov 7; 289 (45):31503-12. doi: 10.1074/jbc.M114.575472.

He Y#, Hao Q, Li W, Yan C, Yan N*, Yin P*. Identification and characterization of ABA receptors in Oryza sativa. PloS One.  2014,9(4): e95246.  doi:10.1371/journal.pone.0095246 2014 Apr 17;

2013

Yin P#, Li Q#, Yan C, Liu Y, Liu J, Yu F, Wang Z, Long J, He J, Wang H, Wang J, Zhu J, Shi Y, Yan N*. Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature. 2013,504 (7478): 168-171. doi: 10.1038/nature12651. 2013 Dec 5;