殷平【教授，博士生导师】

邮箱

yinping@mail.hzau.edu.cn

电话

027-87285221

工作单位

华中农业大学生命科学技术学院

研究方向

1. 线粒体和叶绿体蛋白转运机制

2. 光受体和光信号传递分子机制

3. 核酸修饰鉴定与疾病诊断治疗

教育经历

2006/09-2009/06    武汉大学，生命科学学院生物化学系，博士
2003/09-2006/06    武汉大学，生命科学学院生物化学系，硕士

1999/09-2003/06    武汉大学，生命科学学院生物技术系，学士

主要职历

2013.09− Present   Professor2009.07−2013.08    清华大学，生命科学学院&生命科学联合中心  博士后

2017.05 - 至今 华中农业大学生命科学与技术学院 副院长

2017.05 - 至今 华中农业大学作物遗传改良国家重点实验室 副主任

2013.09− 至今 华中农业大学，生命科学技术学院 教授、博士生导师

2009.07−2013.08 清华大学，生命科学学院&生命科学联合中心 博士后

2013.09− 今          华中农业大学，生命科学技术学院  教授、博士生导师

所获荣誉

2011年获清华大学优秀博士后奖励；

2014年指导的本科生毕业论文《参与叶绿体RNA编辑DYW1蛋白的原核表达纯化研究》(作者：张群霞)被评为湖北省优秀本科生毕业论文。

2015年获华中农业大学第十二届青年教师讲课竞赛二等奖；同年获霍英东教育基金会青年教师基金资助；2015年被评为2014-2015年度“优秀班主任”；

2017年被聘为教育部“长江学者奖励计划”青年学者；获国家自然科学基金优秀青年科学基金资助；同年入选国家第三批青年拔尖人才；入选全国优秀创新创业导师人才库；荣获湖北省青年五四奖章。

2017年指导学生刘建在第十五届“挑战杯”中国银行全国大学生课外学术科技作品竞赛中荣获全国二等奖；指导学生王祥、黄金波在第一届全国农林院校科技竞赛“大北农杯”中荣获特等奖；

2018年指导的“RNA代谢通路研究团队”荣获中国青少年科技创新奖励基金支持的“小平科技创新团队”称号；指导学生王强、官泽源在第二届全国农林院校科技竞赛“大北农杯”荣获三等奖；指导的博士学位论文《人工设计的PPR蛋白特异靶标RNA的机制研究》（作者：申翠翠）被评委2017-2018学年度校级优秀学位论文；

2019年被评为2018-2019年度“优秀班主任”；获“高等学校科学研究优秀成果奖——自然科学奖”二等奖（第二完成人）；

2021年获中国农学会青年科技奖,华中农业大学2020年度教学质量优秀一等奖。

科研成果

2021

1.      Wang Q^#, Guan Z^#, Qi L^#, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P*. Structural insight into the SAM-mediated assembly of mitochondrial TOM core complex. Science, 2021,373 (6561):1377-1381.

2.      Zhan X^#, Xue Y ^#, Guan Z^#, Zhou C, Nie Y, Men S, Wang Q, Shen C, Zhang D, Jin S, Tu L^*, Yin P^*, and Zhang X^*. Structural insights into homotrimeric assembly of cellulose synthase CesA7 from Gossypium hirsutum. Plant Biotechnology Journal, 2021,19 (8):1579-1587.

3. Guan Z^#, Yan L^#, Wang Q, Qi L, Hong S, Gong Z, Yan C^*, and Yin P^*. Structural insights into assembly of Human Mitochondrial Translocase TOM Complex. Cell Discovery, 2021,7(1):22.

4. Qi L^#, Wang Q^#, Guan Z^#, Wu Y, Shen C, Hong S, Cao J, Zhang X, Yan C*, Yin P*. Cryo-EM structure of the human mitochondrial translocase TIM22 complex. Cell Research, 2021,31(3):369-372.

2020

1.        Ma L, Guan Z, Wang Q, Yan X, Wang J, Wang Z, Cao J, Zhang D, Gong X*, Yin P*. Structural insights into the photoactivation of Arabidopsis CRY2. Nature Plants, 2020,6(12) :1432-1438.

2. Shen C^#, Liu H^#, Guan Z, Yan J, Zheng T, Yan W, Wu C, Zhang Q, Yin P*, Xing Y* . Structural Insight into DNA Recognition by CCT/NF-YB/YC Complexes in Plant Photoperiodic Flowering. The Plant Cell, 2020,32(11):3469-3484.

3.        Ma L^#, Wang X^#, Guan Z^#, Wang L, Wang Y, Zheng L, Gong Z, Shen C, Wang J, Zhang D, Liu Z, Yin P*. Structural insights into BIC mediated inactivation of Arabidopsis cryptochrome 2. Nature Structural & Molecular Biology, 2020,27(5):472-479.

4. Yan J^#, Hong S^#, Guan Z, He W, Zhang D, Yin P*. Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1. Nature Communications, 2020,11(1):1417.

2019

1.        Yan J^#, Yao Y^#, Hong S, Yang Y, Shen C, Zhang Q, Zhang D, Zou T, Yin P*. Delineation of pentatricopeptide repeat codes for target RNA prediction. Nucleic Acids Research, 2019,47(7): 3728-3738.

2.        Huang J^#, Dong X^#, Gong Z^#, Qin L, Yang S, Zhu Y, Wang X, Zhang D, Zou T, Yin P*, Tang C*. Solution structure of the RNA recognition domain of METTL3-METTL14 N⁶-methyladenosine methyltransferase. Protein & Cell, 2019,10(4):272-284.

2018

1.      Wang X, Guan Z, Gong Z, Yan J, Yang G, Liu Y, Yin P^*. Crystal structure of WA352 provides insight into cytoplasmic male sterility in rice. Biochemical Biophysical Research Communications, 2018,501(4):898-904.

2. Huang J, Yin P^*. Structural Insights into N-6-methyladenosine (m(6)A) Modification in the Transcriptome. Genomics Proteomics Bioinformatics, 2018,16(2):85-98.

3. Ma L, Wang Q, Yuan M, Zou T, Yin P*, Wang S*. Xanthomonas TAL effectors hijack host basal transcription factor IIA α and γ subunits for invasion. Biochemical Biophysical Research Communications, 2018,496(2):608-613.

4. Wang Q^#, Zhang D^#, Guan Z, Li D, Pei K, Liu J, Zou T, Yin P*. DapF stabilizes the substrate-favoring conformation of RppH to stimulate its RNA-pyrophosphohydrolase activity in Escherichia coli. Nucleic Acids Research, 2018,46(13): 6880-6892.

5. Liu J, Guan Z, Liu H, Qi L, Zhang D, Zou T, Yin P*. Structural insights into the substrate recognition mechanism of Arabidopsis GPP-bound NUDX1 for noncanonical monoterpene biosynthesis. Molecular Plant, 2018,11(1):218-221.

6. Yan J, Zhang Q, Yin P*. RNA editing machinery in plant organelles. Science China-Life Sciences, 2018,61(2):162-169.

2017

1. Yan J^#, Zhang Q^#, Guan Z, Wang Q, Li L, Ruan F, Lin R, Zou T, Yin P*. MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing. Nature Plants, 2017,3(5):17037.

2. Wang X, Huang J, Zou T, Yin P*. Human m6A writers: Two subunits, 2 roles. RNA Biology, 2017,14(3):300-304.

3. Zhao W^#, Zhou C^#, Guan Z, Yin P^*, Chen F^* and Tang Y^*. Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS Chemical Biology, 2017,12 (3):746–752.

2016

1.      Zhang D^#, Liu Y^#, Wang Q, Guan Z, Wang J, Liu J, Zou T, Yin P*. Structural basis of prokaryotic NAD-RNA decapping by NudC. Cell Research, 2016,26(9): 1062-1066.

2.      Wang X^#, Feng J^#, Xue Y^#, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P*. Structural basis of N⁶-adenosine methylation by the METTL3–METTL14 complex. Nature, 2016,534(7608):575-578.

3.      Shen C^#, Zhang D^#, Guan Z^#, Liu Y, Yang Z, Yang Y, Wang X, Wang Q, Zhang Q, Fan S, Zou T, Yin P*. Structural basis for the specific single-stranded RNA recognition by designer pentatricopeptide repeat protein. Nature Communications, 2016,7:11285.

2015

1.      Shen C^#, Wang X^#, Liu Y, Li Q, Yang Z, Yan N, Zou T, Yin P*. Specific RNA recognition by designer pentatricopeptide repeat protein. Molecular Plant, 2015,8(4): 667-670.

2014

1.      Li Q, Yan C, Xu H, Wang Z, Long J, Li W, Wu J, Yin P^*, Yan N*. Examination of the dimerization states of the single-stranded RNA-recognition protein PPR10. Journal of Biological Chemistry, 2014,289 (45):31503-31512.

2.      He Y, Hao Q, Li W, Yan C, Yan N^*, Yin P^*. Identification and characterization of ABA receptors in Oryza sativa. PLoS One, 2014,9(4): e95246.

2013

1. Yin P^#, Li Q^#, Yan C, Liu Y, Liu J, Yu F, Wang Z, Long J, He J, Wang H, Wang J, Zhu J, Shi Y, Yan N^*. Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature, 2013,504 (7478): 168-171.

2012

1.        Lu P^#, Lu G^#, Yan C, Wang L, Li W, Yin P*. Structure of the mRNA splicing complex component Cwc2: insights into RNA-recognition. Biochemical Journal, 2012 Jan 15;441(2):591-7.

2. Yin P^#, Deng D^#, Yan C, Pan X, Xi J, Yan N, Shi Y*. Specific DNA-RNA hybrid recognition by TAL effectors. Cell Reports, 2012,2 (4):707-13.

3.        Deng D^#, Yin P^#, Yan C, Pan X, Gong X, Qi S, Xie T, Mahfouz M, Zhu Jian-Kang, Yan N*, Shi Y*. Recognition of methylated DNA by TAL effectors. Cell Research, 2012, 22 (10):1502-4.

Prior to 2012

1.        Hao Q^#, Yin P^#, Li W, Wang L, Yan C, Lin Z, Wu J, Wang J, Yan S, Yan N*. The molecular basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins. Molecular Cell, 2011,42(5):662-72.

2.        Yuan X^#, Yin P^#, Hao Q^#, Yan C, Wang J, Yan N*. Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2. Journal of Biological Chemistry, 2010,285 (37): 28953-8.

3.        Hao Q^#, Yin P^#, Yan C#, Yuan X, Li W, Zhang Z, Liu L, Wang J, Yan N*. Functional mechanism of the abscisic acid agonist pyrabactin. Journal of Biological Chemistry, 2010,285 (37): 28946-52.

4. Yin P^#, Fan H^#, Hao Q^#, Yuan X^#, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N*. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nature Structural & Molecular Biology, 2009,16 (12): 1230-6.

5. Yin P, Li T, Xie M, Jiang L, Zhang Y*. A Type Ib ParB protein involved in plasmid partitioning in a gram-positive bacterium. The Journal of Bacteriology, 2006,188 (23): 8103-8.

6.        Li T^#, Yin P^#, Zhou Y, Zhang Y*, Zhang Y, Chen T. Characterization of the replicon of a 51-kb native plasmid from the gram-positive bacterium Leifsonia xyli subsp. Cynodontis. FEMS Microbiol Lett, 2004,236 (1): 33-9.